Agree it’s dependent on your personal values and goals. I prefer environmental causes and also try to help smaller local animal rescues because they’re often run on shoestring budgets so a little goes a long way, whereas bigger non-profits have access to more resources.

Would recommend researching whatever you end up choosing.Many charities spend a lot of money on executive pay or marketing vs. core programs. I’ll usually check annual reports for budgets or see if they’re on Charity Navigator.